Site using hand-drawn style in subtle way with paper imitation and charming page fold.

Warning - Flash site image below imitating workspace on Your office, using handwriting notes, photos.

Sites using just a few design elements to get that personal look with sewing cloth imitation and cute box layout roundup margins.

Sometimes entirely hand drawn sites can look amazing, but shouldn’t forget about usability since it’s easy to overuse this technique:

Portfolio website using a lot of sketched elements to express their creativity.

Kind of childish looking site but in the same time - very good example:

Use ribbons in navigation or titles to get really special fashioned 3D effect

Vintage/Grunge sites using hand drawn elements:

More like vintage style page using old paper, paper folds, stickers:

Excellent example of hand writing font usage in navigation, logotype and also notice creative contact boxes  in the footer and sketched arrow. Simple and creative design.

Fuzzy lines, shapes, handwriting text and polaroid photo imitation looks really good:

Header using paper background and dashed (dotted could look good too) line with scissors.

Sites using leather or fabric elements in their background or navigation with stitches.

I think also wood texture in backgrounds is also very typical hand-drawn style feature and there are many examples showing why :

This site could be more considered vintage/grunge style website, but there are also very good examples of background usage, polaroid photos, wood materiality and map.

Site using table surface as background with many typical hand-drawn style daily use things, stickers, papers, pins, handwriting text and so on.

Go crazy being creative - whole site is dedicated to represent Your workspace and tools You are using. (warning:flash site)

Creative board with lot’s of notes, pins, badges, checks and handwriting text.

http://www.1stwebdesigner.com/inspiration/46-sites-to-get-inspired-and-familiar-with-hand-drawing-style/